Effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage
10.3760/cma.j.cn311847-20210106-00008
- VernacularTitle:微创碎吸引流联合高压氧治疗对高血压脑出血患者炎性因子及脑血管动力学的影响
- Author:
Yafeng LIU
1
;
Yifang WANG
1
;
Qing WANG
1
;
Cheng YU
1
;
Shicui XIA
1
;
Hulong MA
1
;
Mengqi XU
1
Author Information
1. 211100 南京，南京紫金医院
- Publication Type:Journal Article
- Keywords:
Minimally invasive aspiration and drainage;
Hyperbaric oxygen;
Hypertensive cerebral hemorrhage;
Inflammatory factors;
Cerebrovascular dynamics
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(4):437-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of minimally invasive aspiration and drainage combined with hyperbaric oxygen (HBO) therapy on inflammatory factors and cerebrovascular dynamic indicators in patients with hypertensive intracerebral hemorrhage.Methods:A total of 74 patients with hypertensive intracerebral hemorrhage treated in 454 Hospital and Nanjing Zijin Hospital from January 2019 to January 2021 were selected and randomly divided into treatment group ( n=37) given minimally invasive aspiration and drainage combined with HBO therapy and control group ( n=37) given minimally invasive aspiration and drainage only. The levels of serum inflammatory factors, cerebrovascular dynamic indicators, arterial blood gas (ABG) levels, and the neurologic function scores in the two groups before and after treatment were compared. Results:Before treatment, there was no significant difference between the two groups in the levels of serum inflammatory factors, cerebrovascular dynamic indicators, ABG levels, and the neurological function scores ( P>0.05); after 30 days of treatment, the levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1(IL-1), and IL-8 in the treatment group were lower than those in the control group, the National Institute of Health Stroke Scale (NIHSS) scores, the values of peripheral resistance (PR) and dynamic resistance (DR) in the treatment group were lower than those in the control group, while the Mini-mental State Examination (MMSE) scores, the mean blood flow velocities (Vm), mean blood flow quantities (Qm), the arterial partial pressures of CO 2 (PaCO 2) and the arterial partial pressures of oxygen (PaO 2), and the blood pH values in the treatment group were higher than those in the control group ( P<0.05), and all the differences were statistically significant ( P<0.05). Conclusion:Minimally invasive aspiration and drainage combined with HBO therapy in the treatment of hypertensive intracerebral hemorrhage can effectively reduce the patients’ inflammatory response and promote the recovery of cerebral vascular dynamics and nerve function.
