Effects of hyperbaric oxygen combined with fibroblast growth factor on skin wound healing and serum indicators
10.3760/cma.j.cn311847-20200508-00186
- VernacularTitle:高压氧联合成纤维细胞生长因子治疗皮肤创伤对患者创面愈合与血清指标的影响
- Author:
Zhi YANG
1
;
Xiaohua SHI
;
Tian TIAN
;
Mingjia JIN
;
Yang GAO
Author Information
1. 401120 重庆，重庆医科大学附属第三医院皮肤整形美容中心
- Publication Type:Journal Article
- Keywords:
Skin wound;
Hyperbaric oxygen;
Fibroblast growth factor;
Inflammatory factor
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(4):484-488
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of hyperbaric oxygen combined with fibroblast growth factor (FGF) on skin wound healing and serum indicators.Methods:A total of 84 patients with skin wounds treated at the Third Affiliated Hospital of Chongqing Medical University between March 2017 and July 2019 were selected and evenly divided into observation group and control group (42 cases in each group) using a random number table. The control group was treated with human FGF; and the observation group was additionally treated with hyperbaric oxygen. The wound healing time and wound healing rate after 15 days of treatment in the two groups were recorded. The wound exudate was collected before treatment and on the 5th, 10th, and 15th days of treatment. Enzyme-linked immunosorbent assay (ELISA) was used to measure the wound serum inflammatory factor C-reactive protein (CRP), the levels of tumor necrosis factor-α (TNF-α), and the levels of wound serum indicators interleukin-33 (IL-33), soluble suppression of tumorigenicity 2 (sST2), transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), and vascular endothelial growth factor (VEGF). The itching and reddening of the skin lesions were also observed besides other adverse reactions.Results:After 15 days of treatment, the wound healing time in the observation group was shorter than that of the control group; and the wound healing rate was significantly higher than that in the control group; the differences were statistically significant ( P<0.05). On the 5th, 10th, and 15th days of treatment, the CRP and TNF-α levels in both groups were reduced than those before the treatment. Moreover, the levels of CRP and TNF-α in the observation group were distinctly lower than those in the control group, and the differences were statistically significant ( P<0.05 and P<0.01, respectively). On the 5th, 10th, and 15th days of treatment, the wound lesion serum levels of IL-33 and sST2 in both groups were significantly reduced, and the levels of IL-33 and sST2 in the observation group were significantly lower than those in the control group ( P<0.05). On the 5th, 10th, and 15th days of treatment, the wound lesion serum levels of TGF-β1, VEGF, and CTGF in both groups were significantly increased after treatment, and the levels of TGF-β1, VEGF, and CTGF in the observation group were significantly higher than those in the control group, and the differences were statistically significant ( P<0.05 and P<0.01, respectively). During the inpatient treatment, the incidence of adverse reactions, such as itching and reddening of the skin lesion, was lower than expected, and there was no significant difference between the two groups ( P>0.05). Conclusion:Hyperbaric oxygen combined with FGF in the treatment of patients with skin wounds produces better curative effects and reduce risks, through regulating the levels of inflammatory factors and promoting factors for skin wound repair.
