Correlations of quantitative 99Tcm-MIBI SPECT/CT imaging parameters,functional markers and disease severity of parathyroid adenoma-related primary hyperparathyroidism
10.13929/j.issn.1672-8475.2024.12.007
- VernacularTitle:甲状旁腺腺瘤相关原发性甲状旁腺功能亢进症定量99Tcm-MIBI SPECT/CT显像参数与功能标志物及疾病严重程度的相关性
- Author:
Shuheng LI
1
;
Jiusong LUAN
;
Xi DONG
;
Jian SU
;
Xiaodong LI
Author Information
1. 河北大学附属医院核医学科,河北保定 071000;河北省炎症相关肿瘤精准影像学重点实验室,河北保定 071000
- Publication Type:Journal Article
- Keywords:
hyperparathyroidism,primary;
parathyroid neoplasms;
tomography,emission-computed,single-photon;
technetium Tc 99m sestamibi
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(12):756-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlations of quantitative 99Tcm-methoxyisobutylisonitrile(99Tcm-MIBI)SPECT/CT imaging parameters,functional markers and disease severity of primary hyperparathyroidism(PHPT)related to parathyroid adenoma.Methods Fifty-eight patients with PHPT due to single parathyroid adenoma were retrospectively collected,clinical data including serum parathyroid hormone(PTH)levels were recorded,and quantitative 99Tcm-MIBI SPECT/CT imaging parameters were obtained.According to serum calcium level reflecting disease severity(2.55-2.80 mmol/L or＞2.80 mmol/L),the patients were categorized into type Ⅰ group(n=25)and type Ⅱ group(n=33).Quantitative metabolic parameters of lesions,i.e.standard uptake value(SUV)values(the maximum SUV[SUVmax],the mean SUV[SUVmean],the peak SUV[SUVpeak]),SUV values normalized by lean body mass(SUL,including the maximum SUL[SULmax],the mean SUL[SULmean]and the peak SUL[SULpeak]),total lesion volume(TLV)and total lesion uptake(TLU),as well as derived parameters such as lesion to background ratio(LBR)contrast to contralateral deltoid muscle and lesion density(LD)were obtained from reconstructed images and compared between groups.The area under curves(AUC)of the receiver operating characteristic(ROC)curves were used to evaluate the performance of each index and their combined logistic regression model for distinguishing the severity of PHPT.Results The serum PTH and serum calcium levels in type Ⅰ group were both significantly lower than those in type Ⅱ group(both P＜0.05).No statistically significant difference of detection rate of parathyroid adenoma with PHPT was found between 99Tcm-MIBI SPECT/CT and planar imaging(96.56％vs.91.38％,P=0.063).TLV and TLU were weakly correlated with serum PTH(rs=0.416,0.422)and serum calcium levels(rs=0.391,0.349)(all P＜0.05).TLV and TLU values in type Ⅰgroup were significantly lower than those in type Ⅱ group(both P＜0.05).The AUC of PTH,TLV and TLU for differentiating type Ⅰ and type Ⅱ PHPT related to parathyroid adenoma was 0.770,0.741 and 0.716,respectively,of the combination of all the three was 0.790,and no statistical difference was detected(Z=0.361-1.454,all P＞0.05).Conclusion 99Tcm-MIBI SPECT/CT quantitative metabolic parameters TLV and TLU could be used to evaluate the functional status of parathyroid and severity of PHPT related to parathyroid adenoma.
