Intravascular ultrasound elastography for evaluating efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaques
10.13929/j.issn.1672-8475.2024.12.005
- VernacularTitle:血管内超声弹性成像评估依折麦布联合瑞舒伐他汀治疗颈动脉粥样硬化斑块效果
- Author:
Wei CAO
1
;
Jie ZHANG
;
Haiyan ZHANG
;
Yu WANG
;
Lin CAO
;
Lingtao TANG
Author Information
1. 邢台市中心医院体检中心,河北邢台 054000
- Publication Type:Journal Article
- Keywords:
cerebrovascular disorders;
elasticity imaging techniques;
ezetimibe;
rosuvastatin;
plaque,atherosclerotic;
prospective studies
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(12):747-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of intravascular ultrasound elastography(IVUSE)for evaluating efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaques.Methods Totally 200 ischemic cerebrovascular disease patients were prospectively enrolled and randomly divided into study group and control group(each n=100).Patients in study group were treated with ezetimibe combined with rosuvastatin,while those in control group were treated with atorvastatin alone for 4 months.The score of National Institutes of Health stroke scale(NIHSS)and related indicators of laboratory examination were recorded before and after treatment.Routine carotid artery ultrasound and IVUSE examination were performed,their efficacy for detecting vulnerable carotid plaque were compared taken the results of digital subtraction angiography(DSA)and CT before treatment as standards.The changes of clinical data,IVUSE parameters and stability of carotid plaque after treatment were observed.Results DSA detected single plaque in 162 cases and multiple plaques in 38 cases,with a total of 232 plaques,including 192 vulnerable plaques and 40 stable plaques.The accuracy of IVUSE for detecting vulnerable carotid plaque was higher than that of conventional ultrasound(x2=16.019,P＜0.001).After treatment,NIHSS score,total cholesterol,triglycerides,low-and high-density lipoprotein cholesterol improved better in study group than those in control group.Eccentric index and strain rate were higher,while the other plaque IVUSE parameters were lower in study group than those in control group(all P＜0.05).The improvement rate of plaque stability in study group after treatment was higher than that in control group(78.00％[78/100]vs.52.00％[52/100],P＜0.001).Conclusion IVUSE could be used to evaluate the efficacy of ezetimibe combined with rosuvastatin for treating carotid atherosclerotic plaque.
