Sclerotherapy of pelvic lymphoid cysts with anhydrous ethanol and lauromacrogol:Efficacy and safety
10.13929/j.issn.1672-8475.2024.12.002
- VernacularTitle:无水乙醇与聚桂醇硬化治疗盆腔淋巴囊肿:有效性及安全性
- Author:
Chuan MOU
1
;
Min HU
;
Qin XIE
;
Jin LI
;
Wensheng YUE
Author Information
1. 川北医学院附属医院超声科,四川南充 637000;宜宾市第二人民医院超声科,四川宜宾 644000
- Publication Type:Journal Article
- Keywords:
pelvis;
lymphocele;
sclerotherapy
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(12):733-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of sclerotherapy of pelvic lymphoid cysts with anhydrous ethanol and lauromacrogol.Methods Totally 98 patients with pelvic lymphatic cysts after resection of gynecological malignant tumors were retrospectively enrolled,including 50 cases underwent sclerotherapy with anhydrous ethanol(anhydrous ethanol group)and 48 cases with lauromacrogol(lauromacrogol group).The complications after sclerotherapy were recorded,and the effect was evaluated according to improvement of symptoms and results of ultrasound,CT or MRI 3 months after sclerotherapy.Results Sclerotherapy was successfully completed in both groups.After sclerotherapy,adverse reactions occurred in 20 cases in anhydrous ethanol group,including pain(n=5),drunk-like reaction(n=2),cyst infection and drug resistance(n=1),intestinal perforation(n=1)and decreased immunity(n=6),among which 2 were common terminology criteria for adverse events(CTCAE)grade 1 and 18 were CTCAE grade 2-3 adverse reactions.Meanwhile,minor pain occurred in 2 cases in lauromacrogol group,both were CTCAE grade 1 adverse reactions.The incidence of CTCAE grade 2-3 adverse reactions in anhydrous ethanol group was higher than in lauromacrogol group(36.00％[18/50]vs.0[0/48],x2=21.168,P＜0.001).All the above adverse reactions in 2 groups improved after symptomatic support treatment,and no other complication was observed.Three months after treatment,4 cases were cured,40 were improved and 6 were ineffective in anhydrous ethanol group,while 7 were cured,40 were improved and 1 was ineffective in lauromacrogol group.No significant difference of cyst control rate was found between groups(88.00％[44/50]vs.97.92％[47/48],x2=4.178,P=0.128).Conclusion The effects of sclerotherapy of pelvic lymphoid cysts with anhydrous ethanol and lauromacrogol were equivalent,while the latter was safer.
