Research progress on materials of patent foramen ovale occlader
10.3969/j.issn.1004-8812.2024.12.008
- VernacularTitle:卵圆孔未闭封堵器材料研究进展
- Author:
Guang-tai ZHOU
1
;
Chao ZHOU
;
Hai-jun ZHANG
Author Information
1. 生物医用材料改性技术国家地方联合工程实验室,山东德州 251100
- Publication Type:Journal Article
- Keywords:
Patent foramen ovale occlader;
Non-degradable materials;
Biodegradable materials
- From:
Chinese Journal of Interventional Cardiology
2024;32(12):709-716
- CountryChina
- Language:Chinese
-
Abstract:
Patent foramen ovale(PFO)is an important risk factor for cardiogenic stroke.With the rapid development of cardiac interventional techniques,PFO occluder has become the first choice for the treatment of PFO.The biocompatibility,mechanical stability of the occluder material and its adaptability to the patient's anatomical structure are key factors in determining the therapeutic effect.Remarkable progress has been made in its research.In the early stage,the occluder was mainly made of metal material.Although it has high sealing effect and operation convenience,there is potential risk of long-term retention in the body.In recent years,biodegradable materials have been widely used in the field of sealers,such sealers are made of biomedical polymer materials,implanted into the human body to play a temporary bridge role,guide self-tissue bioremediation,and gradually degrade into harmless substances discharged from the body,avoiding the long-term retention of metal sealers.This paper reviews the research progress of PFO occluder materials,including the application of non-degradable materials and biodegradable materials,and discusses the limitations of the current research and the possible development trend in the future,so as to provide reference for clinical application.
