Diagnostic value of contrast-enhanced ultrasound quantitative analysis in differentiating benign and malignant subpleural lung lesions
10.3760/cma.j.cn311847-20200623-00262
- VernacularTitle:超声造影定量分析在胸膜下肺病灶良恶性鉴别中的诊断价值
- Author:
Yi ZHANG
1
;
Ke BI
;
Huiming ZHU
;
Yang CONG
;
Mengjun SHEN
;
Hongwei CHEN
;
Yin WANG
Author Information
1. 200433 上海，同济大学附属上海市肺科医院超声科
- Publication Type:Journal Article
- Keywords:
Contrast-enhanced ultrasound;
Quantitative analysis;
Lung tumor;
Subpleural;
Arrival time
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(4):494-498
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the diagnostic value of the quantitative analysis of contrast-enhanced ultrasound (CEUS) in differentiating benign and malignant subpleural lung lesions.Methods:A total of 299 cases of ultrasound-guided percutaneous lung puncture in Shanghai Pulmonary Hospital Affiliated to Tongji University from January 2019 to June 2019 were selected and divided into benign group and malignant group. The time-intensity curve (TIC) parameters of CEUS before puncture in both groups were reviewed and compared with the corresponding pathological results, including the arrival time (AT), the AT intensity, the time to peak intensity (TTP), and maximum intensity (IMAX) of the lesions, the net enhancement of intensity of the lesions, the reduced-by-half intensity and the reduced-by-half time of the lesions, the AT difference between the lesions and the lung tissues, the AT difference between the chest wall and the lesions, and the time ratio. The receiver operating characteristic (ROC) curves were drawn, and the area under the curve (AUC) and the optimal cut-off point were calculated.Results:Among the quantitative parameters of CEUS, there were statistically significant differences between the benign group and malignant group in terms of the AT, AT intensity, TTP, the reduced-by-half intensity and time of the lesions, the AT difference between the lesions and the lung tissues, the AT difference between the chest wall and the lesions, and the time ratio ( P<0.05); while there was no statistically significant difference between the benign group and malignant group in terms of the IMAX and the net enhancement of intensity of the lesions ( P>0.05). The AUC of time ratio was the largest (0.845); the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 86.2%, 79.3%, 84.3%, 92%, and 68%, respectively, when the time ratio was at or above 51.89%. Conclusion:Multiple TIC parameters of CEUS quantitative analysis have shown significant differences in differentiating benign and malignant subpleural lung lesions, especially, the parameter of time ratio can provide a basis for clinical differential diagnosis.
