Expression of cell adhesion molecules in paracancerous liver tissue after transcatheter arterial embolization of VX2 hepatocarcinoma in rabbits models and relative mechanisms
10.13929/j.issn.1672-8475.2024.12.011
- VernacularTitle:经导管动脉栓塞治疗兔VX2肝癌模型后癌旁肝组织细胞黏附分子表达及其相关机制
- Author:
Yajing WU
1
;
Zhengliang LI
1
;
Zhou ZHOU
1
Author Information
1. 大理大学第一附属医院放射科,云南大理 671000
- Publication Type:Journal Article
- Keywords:
rabbits;
liver neoplasms;
embolization,therapeutic;
cell adhesion molecules
- From:
Chinese Journal of Interventional Imaging and Therapy
2024;21(12):777-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of cell adhesion molecules in paracancerous liver tissue after transcatheter arterial embolization(TAE)of VX2 hepatocarcinoma in rabbit models and relative mechanisms.Methods Forty-five rabbit models of VX2 hepatocarcinoma were randomly divided into TAE group(embolizing tumor blood supplying arteries with lipiodol),angiography group(hepatic arteriography)and control group(without treatment)(each n=15).The glutamic-pyruvic transaminase(GPT)and glutamic-oxaloacetic transaminase(GOT)3 days after relative managements,as well as levels of NF-κB and cell adhesion molecules were compared among groups.Results GPT,GOT,positive proportion of NF-κB,intercelluar adhesion molecule(ICAM)-1,vascular cell adhesion molecule(VCAM)-1 in TAE group was(173.92±3.61)U/L,(102.76±2.86)U/L,73.33％(11/15),(3.43±0.10)ng/L and(2.18±0.03)ng/L,respectively,the above indexes and mRNA expression of NF-κB,ICAM-1 and VCAM-1 were all higher than those in angiography group and control group(all P＜0.05).No significant difference of the above indexes was found between angiography group and control group(all P＞0.05).Conclusion The expression of cell adhesion molecules in paracancerous liver tissue increased after TAE of VX2 hepatocarcinoma rabbit models,which might be related to NF-κB signaling pathway.
