Predictive value of preoperative prognostic nutritional index on postoperative outcome after transarterial chemoembolization in hepatocellular carcinoma patients
10.3969/j.issn.1002-1671.2025.01.026
- VernacularTitle:术前预后营养指数对肝细胞癌患者经动脉化疗栓塞术术后结局的预测价值
- Author:
Gang LI
1
;
Genfa YI
1
;
Wei ZHAO
1
;
Junchao WANG
1
;
Zhengxin DUAN
1
Author Information
1. 昆明医科大学第一附属医院介入科,云南 昆明 650032
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
transarterial chemoembolization;
inflammatory index;
prognosis
- From:
Journal of Practical Radiology
2025;41(1):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of preoperative prognostic nutritional index(PNI)for postoperative out-comes of patients with hepatocellular carcinoma(HCC)undergoing transarterial chemoembolization(TACE).Methods The clinical datas of 142 HCC patients treated with TACE as initial treatment were retrospectively collected.According to the cut-off value deter-mined by the receiver operating characteristic(ROC)curve,the preoperative systemic immune-inflammation index(SII),PNI,aspar-tate aminotransferase-neutrophil ratio(ANRI),aspartate aminotransferase-lymphocyte ratio(ALRI)and aspartate aminotransferase-platelet ratio(APRI)were divided into high group and low group,and their effects of TACE on postoperative outcome were ana-lyzed.Results Preoperative PNI was negatively correlated with liver function 1 week after TACE.Preoperative PNI and tumor size were independent risk factors for overall survival(OS).The PNI≥42.35 group was better than PNI<42.35 group(OS 28 months vs 10 months),the tumor size<5 cm was better than tumor size≥5 cm(OS 37 months vs 11 months),and the differences were statistically significant(P<0.05).PNI was an independent risk factor for progression-free survival(PFS).The PNI≥42.35 group was better than PNI<42.35 group(PFS 6 months vs 3 months),and the difference was statistically significant(P<0.05).Conclusion Preop-erative PNI has a certain prognostic value in HCC patients,and the OS and PFS of HCC patients with PNI<42.35 group after TACE are shorter.
