Predictive factors and predictive model for prognosis of migraine patients with patent foramen ovale after occlusion
10.13929/j.issn.1672-8475.2025.07.008
- VernacularTitle:偏头痛合并卵圆孔未闭封堵后预后预测因素及模型
- Author:
Yanni WU
1
;
Chao TANG
;
Linlin MA
;
Xia ZHANG
;
Hui LI
Author Information
1. 苏州大学附属第二医院心血管内科,江苏 苏州 215004
- Publication Type:Journal Article
- Keywords:
migraine disorders;
foramen ovale,patent;
septal occluder device;
echocardiography,transesophageal;
contrast media
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(7):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen out the predictive factors for prognosis of migraine patients with patent foramen ovale(PFO)after occlusion,and to observe the value of predictive model based on these factors.Methods A total of 102 migraine patients with PFO who underwent occlusion of PFO were retrospectively included.Based on right to left shunt(RLS)grade in contrast-enhanced transcranial Doppler(TCD)and changes of migraine disability assessment(MIDAS)grade after occlusion,the patients were divided into effective group(n=56)and ineffective group(n=46).Patients'basic data and imaging data including contrast-enhanced TCD and transesophageal echocardiography(TEE)before occlusion were compared between groups.Independent predictive factors were screened using multivariate logistic regression,then a predictive model was established,and its performance was evaluated.Results Compared with ineffective group,effective group had a lower proportion of female patients,a higher proportion of patients with aura symptoms,also higher MIDAS scores before occlusion,lower left to right shunt(LRS)velocities through the defect,and higher RLS grades in contrast-enhanced TCD and TEE right heart contrast echocardiography before occlusion(all P＜0.05).Patients'gender,LRS velocity through the defect and RLS grade in TEE right heart contrast echocardiography before occlusion were all predictive factors for prognosis of migraine patients with PFO after occlusion of PFO(all P＜0.05).The established model demonstrated good discrimination,calibration and clinical net benefit.Conclusion Patients'gender,LRS velocity through the defect and RLS grade in TEE right heart contrast echocardiography before occlusion were all significant predictors of prognosis of migraine patients with PFO after occlusion,and the predictive model established based on these factors demonstrated certain clinical value.
