Diffusion-weighted imaging parameters for evaluating grade of glioma
10.13929/j.issn.1672-8475.2025.07.004
- VernacularTitle:弥散加权成像参数用于胶质瘤分级
- Author:
Dakai WANG
1
;
Yang SHI
;
Min ZHANG
;
Gang CUI
Author Information
1. 邢台医学院第二附属医院CT-MRI科,河北 邢台 054000
- Publication Type:Journal Article
- Keywords:
brain neoplasms;
glioma;
magnetic resonance imaging;
Ki-67
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(7):449-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of diffusion-weighted imaging(DWI)parameters for evaluating grade of gliomas.Methods Totally 116 patients with glioma were retrospectively enrolled and divided into low-grade group(Ⅰ—Ⅱ,n=66)and high-grade group(Ⅲ—Ⅳ,n=50)according to 2000 WHO tumor grading criteria.Clinical and DWI data,including Ki-67 labeling index(LI),apparent diffusion coefficient(ADC),exponential ADC(EADC)and relative ADC(rADC)were compared between groups.The correlations of ADC,EADC and rADC with Ki-67 LI were explored,and the efficacy of above indexes for evaluating grade of glioma was analyzed.Results Significant differences of Ki-67 LI,ADC,EADC and rADC were found between groups(all P＜0.05).ADC and rADC of glioma were negatively correlated(r=-0.565,-0.625,both P＜0.05),while EADC was positively correlated with Ki-67 LI(r=0.587,P＜0.05).ADC,EADC,rADC and Ki-67 LI were all impact factors of grade of glioma(all P＜0.05),with the area under the curve of 0.768,0.802,0.788 and 0.793,respectively,and AUC of the combination of the four was 0.874,significantly higher than each index alone(all P＜0.05).Conclusion ADC,EADC and rADC were helpful for evaluating grade of glioma.Combining with Ki-67 LI could further improve diagnostic efficacy.
