Efficacy of hyperbaric oxygen combined with papaverine in the treatment of non-gangrenous ischemic colitis
10.3760/cma.j.cn311847-20201214-00462
- VernacularTitle:高压氧联合罂粟碱治疗非坏疽性缺血性结肠炎的临床疗效
- Author:
Songcai LI
1
;
Jinbi BEI
;
Chunyu CAO
Author Information
1. 316000 浙江省舟山，舟山市妇女儿童医院消化内科
- Publication Type:Journal Article
- Keywords:
Non-gangrenous ischemic colitis;
Hyperbaric oxygen;
Papaverine;
Superoxide dismutase
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(2):216-219,228
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of hyperbaric oxygen combined with papaverine in the treatment of non-gangrenous ischemic colitis.Methods:A total of 94 cases of non-gangrenous ischemic colitis admitted to the Department of Gastroenterology of Zhoushan Women and Children Hospital from January 2018 to June 2019 were randomly divided into hyperbaric oxygen treatment group and control group with 47 cases in each group. The control group received conventional symptomatic supportive treatment and papaverine treatment, and the hyperbaric oxygen treatment group received conventional symptomatic supportive treatment and hyperbaric oxygen combined with papaverine treatment. Both two groups received continuous treatment for 2 weeks. The clinical indicators, hemorheological indicators, serum superoxide dismutase (SOD) activity, adverse reactions, and clinical efficacies of the two groups were compared.Results:The clinical indicators such as the time to abdominal pain relief, the time to tenderness relief, the time to the disappearance of fecal occult blood, the time to intestinal function recovery, and the length of hospital stay, in the hyperbaric oxygen treatment group were significantly shorter than those in the control group ( P<0.01). After 2 weeks of treatment, the blood viscosity and the level of blood fibrinogen in the hyperbaric oxygen treatment group were significantly lower than those in the control group ( P<0.01), while the serum level of SOD was significantly higher than that in the control group ( P<0.01). During the treatment, there was no significant difference in gastrointestinal reactions, allergies, or other adverse reactions between the two groups ( P>0.05). The total effective rate of the hyperbaric oxygen treatment group was higher than that of the control group [95.74% (45/47) vs. 80.85% (38/47)]( P<0.05). Conclusion:Hyperbaric oxygen combined with papaverine in the treatment of non-gangrenous ischemic colitis can improve the clinical indicators and hemorheological indicators, and achieve obvious clinical efficacy with a satisfactory safety.
