Associations of right atrial strain-area index and prognosis of pulmonary arterial hypertension
10.3969/j.issn.1004-8812.2024.12.002
- VernacularTitle:右心房应变面积指数与肺动脉高压预后的关系
- Author:
Dong-ling LUO
1
;
Li-fang YANG
;
Tao-ran HUANG
;
Hong-wen FEI
;
Cao-jin ZHANG
Author Information
1. 广东省心血管病研究所,广东省人民医院(广东省医学科学院),南方医科大学,心血管辅助诊断科,广东 广州 510080
- Publication Type:Journal Article
- Keywords:
Right atrial strain;
Right atrial area;
Pulmonary arterial hypertension;
Prognosis
- From:
Chinese Journal of Interventional Cardiology
2024;32(12):670-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between right atrial strain-area index(RASAI,the ratio of right atrial reservoir strain to right atrial area)and the prognosis of pulmonary arterial hypertension(PAH).Methods A total of 91 PAH patients who received treatment at Guangdong Provincial People's Hospital from October 2021 to April 2023 were included.Echocardiographic parameters,including right atrial strain and right atrial area,were measured.The association between the RASAI and PAH prognosis was analyzed.Results After a median follow-up of 17(12,26)months,19 adverse events occurred.Cox regression analysis revealed that for per unit increase in RASAI,the risk of adverse outcomes decreased by 40％(unadjusted model,HR 0.60,95％CI 0.40-0.91,P=0.016).This association remained statistically significant after multivariable adjustment(HR 0.50,95％CI 0.29-0.84,P=0.009).Results from tertile grouping and restricted cubic spline analysis further confirmed that RASAI has a dose-response relationship with adverse prognosis.Patients in the high RASAI group had significantly better prognosis than those in the low RASAI group(multivariable adjusted model,HR 0.21,95％CI 0.06-0.70,P=0.011).Conclusions The right atrial strain-area index is closely related to adverse prognosis and may serve as a potential indicator for therapeutic assessment and prognostic prediction.
