Clinical and endoscopic features of eosinophilic gastrointestinal disease (84 cases)
- VernacularTitle:嗜酸细胞性胃肠道疾病的临床表现及内镜特点(附84例报告)
- Author:
Jinrong WU
1
;
Zhengji SONG
1
Author Information
- Publication Type:Journal Article
- Keywords: eosinophilic gastrointestinal disease (EGID); clinical manifestations; endoscopic features; treatment
- From: China Journal of Endoscopy 2024;30(12):61-68
- CountryChina
- Language:Chinese
- Abstract: Objective Analyze the clinical manifestations,endoscopic and histopathological features of eosinophilic gastrointestinal disease (EGID) to improve the understanding of the EGID and reduce the rate of missed diagnosis and misdiagnosis.Methods A retrospective analysis was conducted on the patients of general information,clinical manifestations,laboratory tests,endoscopic and pathological examinations,treatment prognosis and follow-up of 84 patients.Results With the history of food and drug allergies or allergic diseases in 38.1％ cases (32/84),had a clear predisposition before the onset of illness in 25.0％ (21/84).The main clinical symptom was abdominal pain in 79.8％ (67/84).Peripheral blood eosinophil (EOS) count increased significantly in 63 cases (63/84,75.0％) and EOS percentage (EOS％) increased significantly in 71 cases (71/84,84.5％).14 cases (16.7％) tested positive for serum allergen total immunoglobulin E (IgE) antibodies.Among the 68 cases of abdominal ultrasoud examination,there were 5 cases (5/68,7.4％) of ascites and 2 cases (2/68,2.9％) of pelvis effusion.64 cases were examined by CT,suggesting thickening of digestive tract wall in 13 cases (13/64,20.3％),10 cases were examined by small intestine CT,suggesting thickening and narrowing of digestive tract wall in 6 cases (6/10,60.0％).Endoscopic manifestations were nonspecific manifestations such as hyperemic redness,erosion and ulceration.The pathological examination showed mucosal inflammation with a large number of EOS infiltration,with the highest positive rate of biopsy at the duodenum and terminal ileum (P<0.05).Glucocorticoid therapy in 48 cases and symptomatic supportive care in 36 cases,they all achieved clinical remission (P<0.05).Glucocorticoid therapy remained effective in 5 cases with relapse.Conclusion Abdominal pain is a common clinical manifestation in patients with EGID,often with an elevated EOS count.The imaging and endoscopic findings of EGID lack specificity.Tissue biopsy with a large number of EOS infiltration is critical in the diagnosis.Simple antiallergy with acid-suppressing or application of glucocorticoid therapy has a good prognosis.
