Multiple Myeloma Concurrent with Extramedullary Plasmacytoma of the Breast:A Case Report and Literature Review

VernacularTitle:多发性骨髓瘤合并乳腺髓外浆细胞瘤1例并文献复习
Author: Yuhan LIU ¹ ; Zecheng HE ; Mingyue WANG ; Jie LANG ; Yidong ZHOU ; Changjun WANG
Author Information

1. 中国医学科学院北京协和医院乳腺外科,北京 100730
Publication Type:Journal Article
Keywords: extramedullary plasmacytoma; breast tumors; multiple myeloma; case report
From: Medical Journal of Peking Union Medical College Hospital 2025;16(4):1002-1007
CountryChina
Language:Chinese
Abstract: Extramedullary plasmacytoma(EMP)is a malignant neoplasm characterized by monoclonal plasma cell proliferation originating outside the bone marrow and hematopoietic tissues.The co-occurrence of multiple myeloma(MM)with mammary EMP is clinically rare.This case report describes the diagnostic and therapeutic management of a middle-aged female patient with MM and mammary EMP,accompanied by a litera-ture review.The patient presented with persistent fever and was found to have a right breast mass via PET/CT during routine follow-up for MM.The lesion was biopsy-confirmed as mammary EMP,and the patient subse-quently underwent chemotherapy.This case highlights the critical importance of differential diagnosis between breast cancer and rare hematologic metastatic tumors in early prevention of disease progression.