Effects of hyperbaric oxygen therapy on the reconstruction of benign bone tumors of the limbs after allogeneic bone grafting combined with calcium sulfate pellets
10.3760/cma.j.cn311847-20201231-00485
- VernacularTitle:硫酸钙颗粒结合同种异体植骨术后高压氧治疗对四肢良性骨肿瘤缺损重建的影响
- Author:
Peiqin WANG
1
;
Bing SUN
;
Guangda WANG
Author Information
1. 264000 山东省烟台，烟台山医院南院骨科
- Publication Type:Journal Article
- Keywords:
Benign bone tumor;
Calcium sulfate pellets;
Allogeneic bone;
Hyperbaric oxygen;
Bone graft;
Reconstruction
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(3):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effects of hyperbaric oxygen (HBO) therapy in the treatment of benign bone tumors of the extremities after calcium sulfate pellets combined allogeneic bone grafting.Methods:The clinical data of 129 patients with benign bone tumors of the extremities who underwent bone grafting reconstruction at the Department of Orthopedics of Yantai Mountain Hospital and the Department of Orthopedics (Bone Joints) of Yantai Yuhuangding Hospital between July 2013 and July 2019 were selected and divided into three groups: group A ( n=42 cases) was treated with allogeneic bone grafting; group B ( n=40 cases) was treated with calcium sulfate pellets combined with allogeneic bone grafting; and group C ( n=47 cases) was treated with post-grafting HBO in addition to calcium sulfate pellets combined with allogeneic bone grafting. The clinical outcomes of the three groups were compared. The time of complete absorption and bone healing as well as the quantity of remaining bone defects were recorded. The incision drainage volume and the time when soft tissue swelling disappeared were also noted. X-ray examination was performed before treatment and 1 and 3 months after treatment to calculate the maximum X-ray transverse diameters of benign bone tumors in the three groups. Bone mineral density (BMD) was measured by a dual energy X-ray absorptiometry before treatment and 1 and 3 months after treatment in the three groups. Results:After the treatment, the total effective rates of the group B (72.5%) and the group C (85.1%) were significantly higher than that of the group A (57.1%). The rate of the group C was significantly higher than that of the group B ( P<0.05). The disappearance time of soft tissue swelling and incision drainage volume in the group B and the group C were significantly shorter and lower than those in the group A; while the time of soft tissue swelling disappearance and incision drainage volume in the group C were significantly shorter and lower than those in the group B ( P<0.05). The complete absorption time, bone healing time, and bone defect ratio of the group B and the group C were significantly shorter and than those of the group A; while the complete absorption time, bone healing time, and bone defect ratio of the group C were significantly shorter and than those of the group B ( P<0.05 or P<0.01). One month after the operation, the maximum X-ray diameters of benign bone tumors in the groups B and C were significantly smaller than that in the group A; and that in the group C was significantly smaller than that in the group B ( P<0.05). Three months after the operation, the BMDs of the group B and the group C were significantly higher than that of the group A, and the X-ray maximum transverse diameters of benign bone tumors in these two groups were significantly smaller than that of the group A. The BMD of the group C was significantly higher than that of the group B; and the X-ray maximum transverse diameter of benign bone tumors of the group C was also significantly smaller than that of the group B ( P<0.05). Conclusion:After allogeneic bone grafting combined with calcium sulfate pellets, HBO can reduce tissue edema, improve BMD at the lesion, and promote bone healing. With its significant clinical effects, HBO is beneficial to the reconstruction of benign bone tumors.
