Effect of hyperbaric oxygen therapy on gastrointestinal hormones and immune factors in patients with gastric cancer after laparoscopic radical gastrectomy
10.3760/cma.j.cn311847-20200825-00331
- VernacularTitle:高压氧辅助治疗对胃癌根治术后患者胃肠激素及免疫因子的影响
- Author:
Jie SUN
1
;
Yingming SONG
;
Shuna LI
;
Ru WANG
Author Information
1. 046000 山西省长治，长治医学院附属和平医院胃肠外科
- Publication Type:Journal Article
- Keywords:
Radical gastrectomy;
Laparoscopy;
Hyperbaric oxygen;
Gastrointestinal hormones;
Immune function
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of hyperbaric oxygen therapy on gastrointestinal hormones and immune factors in patients with gastric cancer after laparoscopic radical gastrectomy.Methods:A total of 82 patients received laparoscopic radical gastrectomy in the Heping Hospital Affiliated to Changzhi Medical College of Shanxi Province from May 2018 to December 2019 were selected and divided into observation group and control group by the random number table method, with 41 cases in each group. After laparoscopic radical gastrectomy, only the observation group received hyperbaric oxygen therapy. The operation time, intraoperative blood loss, exhaust time, and hospital stay of the two groups were compared. The levels of gastrointestinal hormones (motilin, gastrin) and T lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD4 + /CD8 +) on the last day before and the third day after operation were compared between the two groups. Results:The exhaust time and hospital stay of the observation group were shorter than those of the control group, and there was statistically significant difference ( P<0.05); the levels of motilin and gastrin of both two groups decreased on the sixth day after operation when compared with those on the last day before operation. Moreover, the levels of motilin and gastrin of the observation group were higher than those of the control group, and there was statistically significant difference ( P<0.05, or P<0.01). On the 6th day after operation, the levels of CD3 +, CD4 +, CD4 + /CD8 + of the two groups decreased when compared with those on the last day before operation, while the CD8 + increased significantly. And the levels of CD3 +, CD4 +, CD8 +, CD4 + /CD8 + in the observation group were higher than those in the control group, and there was statistically significant difference ( P<0.05). However, there was no statistically significant difference ( P>0.05) in terms of the levels of CD8 + of the two groups on the sixth day after the operation. Conclusion:Hyperbaric oxygen therapy on patients with gastric cancer after laparoscopic radical gastrectomy can shorten postoperative exhaust time and hospital stay, and can effectively promote the secretion of gastrointestinal hormones and the recovery of immune function after operation.
