The value of qualitative diagnosis in thyroid nodule evaluated by dual-low-dose CT energy spectral imaging combined with adaptive statistical iterative reconstruction-Veo
10.3969/j.issn.1002-1671.2025.01.007
- VernacularTitle:双低剂量CT能谱成像联合自适应统计迭代重建对甲状腺结节定性诊断价值
- Author:
Aihua HAO
1
;
Chuan FENG
;
Yi QIAN
;
Weifeng QIAN
;
Jibin ZHANG
;
Hong WANG
Author Information
1. 南京医科大学附属苏州医院 放射科,江苏 苏州 215002
- Publication Type:Journal Article
- Keywords:
thyroid nodule;
CT energy spectral imaging;
radiation dose;
contrast agent;
adaptive statistical iterative reconstruction-Veo
- From:
Journal of Practical Radiology
2025;41(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of dual-low-dose CT energy spectral imaging combined with adaptive statis-tical iterative reconstruction-Veo(ASIR-V)in distinguishing benign and malignant thyroid nodules.Methods A total of 242 patients with thyroid nodules were included.In part Ⅰ,the initial 90 patients were randomly and equally assigned to the conventional scan group,the low radiation dose group,and the dual-low-dose group.Both subjective and objective image qualities,the radiation dose,and contrast agent dosage in these three groups were evaluated,respectively.In part Ⅱ,the remaining 152 patients underwent dual-low-dose CT energy spectral scanning.Radiographic features of thyroid nodules in benign and malinant groups were observed,fol-lowed by spectral imaging analysis.The iodine concentration(IC)value,normalized iodine concentration(NIC)value,effective atomic number(Eff-Z),and λHU value of benign and malignant nodules were measured and compared,respectively.Results There were significant differences in nodule morphology,sign of edge truncation,enhancement characteristics and nodule boundary enhancement between benign and malignant thyroid nodules(P<0.05).There were statistically significant differences in IC value,NIC value,and λHU value in the venous phase among the three groups(P<0.05).The sensitivity and specificity of IC,NIC,λHU were 81.6%and 60.0%,86.4%and 67.5%,88.8%and 65.0%,respectively.The area under the curve(AUC)of combining the three energy spectral parameters with radiographic fea-tures via binary logistic regression model was 0.905,and the sensitivity and specificity were 82.4%and 87.5%,respectively.The effective dose(ED)in the dual-low-dose group was reduced by 60.13%com-pared to the conventional scan group,and the contrast agent dos-age was reduced by 38.56%.Conclusion The dual-low-dose CT energy spectral imaging combined with ASIR-V significantly reduced the radiation dose and the contrast agent dosage,and might help in distinguishing between benign and malignant thyroid nodules,demonstrating considerable clinical application value.
