Effect of time intervals of priming continuous theta burst stimulationon on cortical plasticity induced by intermit-tent theta burst stimulation
10.3969/j.issn.1006-9771.2025.05.014
- VernacularTitle:时间间隔对持续性θ爆发刺激预调控间歇性θ爆发刺激诱导运动皮质可塑性的影响
- Author:
Ayan GENG
1
;
Qinglei WANG
;
Junfan SHEN
;
Shizhe ZHU
;
Panpan JI
;
Tong WANG
;
Chuan GUO
Author Information
1. 南京医科大学康复医学院,江苏 南京市 210029;南京医科大学第一附属医院,江苏 南京市 210029
- Publication Type:Journal Article
- Keywords:
theta burst stimulation;
plasticity;
motor-evoked potential;
Bienenstock-Cooper-Munro theory
- From:
Chinese Journal of Rehabilitation Theory and Practice
2025;31(5):607-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of continuous theta burst stimulation-intermittent theta burst stimulation(cTBS-iT-BS)priming protocols with different time intervals on the plasticity of primary motor cortex(M1).Methods A total of 39 healthy young adults were recruited from Changzhou De'an Hospital from March to August,2024.Participants received cTBS-iTBS priming protocols with intervals of 5 minutes,10 minutes and 15 minutes using a randomized crossover design.Motor-evoked potential(MEP)amplitudes in M1 were recorded at baseline(before intervention)and 0 minute,10 minutes,20 minutes and 30 minutes after intervention.Results The main effects of stimulation protocol(F=19.761,P<0.001)and measurement time(F=10.224,P<0.001)were significant.At each time point after intervention,the MEP amplitude was significantly higher under the 10-minute interval than under the 5-minute and 15-minute intervals(t>3.010,P<0.05).Conclusion The 10-minute interval of cTBS-iTBS is more effective on M1 plasticity.
