Effect of hyperbaric oxygen treatment on the serum chemokines and immune T cells in the patients with bronchial asthma and the correlation of the treatment with the activity of cytochrome oxidase
10.3760/cma.j.cn311847-20191126-00341
- VernacularTitle:高压氧治疗对支气管哮喘患者血清趋化因子和免疫T细胞的影响及其与细胞色素氧化酶活性的相关性研究
- Author:
Huiqun SHI
1
;
Chao YAN
;
Haiying YU
;
Yiyi ZHAO
Author Information
1. 130000 长春，吉林大学南岭校区医院检验科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Bronchial asthma;
Chemokines;
Immune T cells;
Cytochrome oxidase
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(1):51-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of hyperbaric oxygen treatment on the serum chemokines and immune T cells in the patients with bronchial asthma, and to analyze the correlation between the treatment and the activity of cytochrome oxidase (COX).Methods:A total of 96 patients with bronchial asthma treated from January 2017 to December 2018 were selected as the research subjects, and were randomly divided into control group and observation group ( n=48). The control group was given the conventional treatment, while the observation group was additionally treated with the hyperbaric oxygen therapy. The changes of serum chemokines and the changes of Th1 and Th2 (subsets of CD 4+ T cells) in the two groups were compared before and after the treatment. The correlation between the hyperbaric oxygen therapy and the COX activity was also analyzed. Results:In the observation group, 38 cases were markedly improved, while only 27 cases in the control group were markedly improved. And the total effective rate of the observation group (95.83%) was significantly higher than that of the control group (85.42%) ( P<0.05). After the treatment, the partial pressure of oxygen (PaO 2), FEV1, FEV1/FVC of the patients in the observation group were significantly increased as compared with those in the control group with statistically significant differences ( P<0.05). The serum eotaxin and monocyte chemoattractant protein-1 (MCP-1) in both two groups after treatment were significantly decreased as compared with those before the treatment, and the serum chemokines of the observation group were sharply reduced compared with that of the control group ( P<0.05). After the treatment, the Th1 in the peripheral blood and the ratio of Th1/Th2 of patients in the two groups increased significantly, while the Th2 decreased significantly. Moreover, the distribution of immune T cell subgroups in the observation group was better than that in the control group. According to person correlation analysis, the levels of eotaxin, MCP-1, and Th2 were negatively correlated with COX activity ( r=-0.635, P=0.004; r=-0.673, P=0.002; r=-0.737, P<0.001), while the Th1 was positively correlated with COX activity ( r=0.684, P=0.001). Conclusion:Hyperbaric oxygen therapy can strengthen the immune function of the patients with bronchial asthma and improve the prognosis by enhancing COX activity and active aerobic metabolism, thus reducing the expression of serum chemokines.
