Effect of hyperbaric oxygen therapy on the healing of the skin flap, the vascular endothelial growth factor, and hypoxia inducing factor-1α after the modified radical mastectomy
10.3760/cma.j.cn311847-20200602-00241
- VernacularTitle:高压氧辅助治疗对乳腺癌术后皮瓣愈合及血管内皮生长因子和缺氧诱导因子的影响
- Author:
Jianjun SHI
1
;
Mengsheng CUI
1
;
Junheng BAI
1
;
Jiequan YANG
1
;
Xiaofei CHANG
1
;
Lili FU
1
;
Honglan NIU
1
Author Information
1. 046000 山西省长治，长治医学院附属和平医院乳腺科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen therapy;
Modified radical mastectomy;
Skin flap healing;
Vascular endothelial growth factor;
Hypoxia inducing factor
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(1):39-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of hyperbaric oxygen (HBO) therapy on the healing of the skin flap, the vascular endothelial growth factor (VEGF) and hypoxia inducing factor-1α (HIF-1α) after modified radical mastectomy.Methods:A total of 132 patients with breast cancer admitted in the Department of Breast Surgery of Heping Hospital Affiliated to Changzhi Medical College from January 2017 to June 2019 were selected as the research subjects and randomly divided into control group ( n=66) and observation group ( n=66). The control group was given the modified radical mastectomy, while the observation group was additionally given hyperbaric oxygen therapy. The postoperative healing condition of incision flap, including healing time, drainage volume, and pain score, was compared between two groups. And the serum VEGF and HIF-1α levels of patients in the two groups were compared before and after the treatment. Besides, postoperative complications were also observed. Results:The healing time of the skin flap in the observation group with HBO [(10.43±0.96) d] was significantly shorter than that in the control group [(13.81±1.15) d]. The drainage volume of the observation group was (274.01±13.10) ml, and the visual analogue scale (VAS) were (4.02±0.34) and (2.84±0.30) on the first and the third day after the operation respectively. The healing condition and VAS scores of the observation group were both better than those in the control group, and all the differences were statistically significant ( P<0.05). Serum VEGF and HIF-1α levels in the observation group were (809.67±40.22) pg/ml and (243.71±22.84) pg/ml respectively, which were significantly improved compared with those before the treatment and those of the control group, and all the differences were statistically significant ( P<0.05). The incidence of postoperative complications in the observation group (3.03%) was lower than that of the control group (10.61%). Conclusion:The hyperbaric oxygen therapy has a significant clinical effect on the patient after the modified radical mastectomy. It can accelerate skin flap healing, relieve patients’ pain, and promote prognosis by reducing HIF-1α level and increasing VEGF content.
