Hyperbaric oxygen therapy on fishery putrefaction gas poisoning and its effects on lung function and inflammatory factors
10.3760/cma.j.cn311847-20200313-00105
- VernacularTitle:高压氧治疗在渔业腐气中毒中的应用及其对患者肺功能、血清炎性因子的影响
- Author:
Yanxia CUI
1
;
Zhenping ZHANG
;
Wei GAO
;
Zhenhong ZHANG
Author Information
1. 264308 山东省荣成，荣成市石岛人民医院呼吸内科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen therapy;
Fishery putrefaction gas poisoning;
Efficacy analysis;
Lung function;
Inflammatory factors
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(6):732-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy of hyperbaric oxygen in the treatment of fishery putrefaction gas poisoning, and to analyze its effects on lung function and inflammatory factors.Methods:A total of 110 patients with anchovy putrefaction gas poisoning admitted to Shidao People’s Hospital of Rongcheng from June 2015 to October 2017 were selected as study subjects and randomly divided into control group ( n=55) and observation group ( n=55). The control group was given conventional symptomatic and supportive treatment, while the observation group was treated with hyperbaric oxygen as an auxiliary treatment. The clinical curative effects of the two groups were observed. The changes in arterial blood gas, pulmonary function, and inflammatory factor levels were also compared before and after treatment. Results:The total effective rate of the observation group was 96.30%, which was significantly higher than that (81.82%) of the control group ( P<0.05). The clinical Glasgow Coma Scale (GCS) score, awakening time, and the length of hospital stay of the observation group were (12.27±1.16), (3.41±1.06) h, and (4.25±1.76) d, respectively, all of which were significantly better than those of the control group ( P<0.05). After treatment, SaO 2, PaO 2, and PaO 2/FiO 2 of both groups increased significantly, while PaCO 2 decreased significantly. PaO 2 and PaO 2/FiO 2 in the observation group showed greater improvements than those in the control group ( P<0.05). After treatment, the lung function of patients in both groups improved, and the FEV 1, FVC, and FEV 1/FVC in the observation group were significantly higher than those in the control group ( P<0.05). The levels of serum inflammatory factors and white blood cell counts in both groups were significantly reduced than those before treatment, and the levels of IL-6, TNF-α, and CRP in the observation group were significantly lower than those in the control group ( P<0.05). Conclusion:Hyperbaric oxygen therapy can effectively improve the lung function of patients with putrefaction gas poisoning, reduce inflammatory reactions and the levels of inflammatory factors, thus improving the total clinical efficacy.
