Research progress on the mechanism of atherosclerosis caused by triglyceride-rich lipoprotein and its residues

VernacularTitle:富含甘油三酯的脂蛋白及其残余物致动脉粥样硬化的机制研究进展
Author: Meiyi LIU ¹ ; Mingyan SHAO ; Yuanyuan GUAN ; Fangli LI ; Lingru LI
Author Information

1. 北京中医药大学,北京市 100029
Publication Type:Journal Article
Keywords: triglyceride; triglyceride-rich lipoprotein; atherosclerosis; medication treatment
From: Chinese Journal of Arteriosclerosis 2025;33(4):355-362
CountryChina
Language:Chinese
Abstract: Triglyceride(TG)is transported in the blood as specific triglyceride-rich lipoprotein(TRL).When TRL is overproduced or the catabolism is not timely,cholesterol ester-rich residues is formed.Both TRL and its residues contribute to the development of atherosclerosis(As)through various direct and indirect mechanisms.Currently,the combination of lifestyle interventions and Western medicines is considered the preferred treatment strategy for As.Howev-er,lipid-lowering therapy alone cannot fully eliminate the residual risk of As.In contrast,traditional Chinese medicine emphasizes the holistic regulation of bodily functions to prevent and treat As.This paper will begin by examining the met-abolic mechanisms of TRL,elucidate the role of TRL and its residues in the risk of As occurrence,and summarize current strategies targeting the TRL metabolic pathway to reduce the incidence of As.