Summary of the Effects of Mitophagy in OA
10.3870/j.issn.1672-0741.24.07.005
- VernacularTitle:线粒体自噬对骨性关节炎的影响
- Author:
Zifeng YE
1
;
Gaoyan KUANG
;
Yiwei YUAN
Author Information
1. 湖南中医药大学第一中医临床学院,长沙 410208;湖南中医药大学第一附属医院骨伤科,长沙 410007
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
mitophagy;
chondrocyte;
mitochondrial homeostasis
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2024;53(6):858-864
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis is the most common degenerative disease in humans,the pathogenesis of which is still un-clear.Mitochondrial impairment dysfunction plays an important role in human aging and degenerative diseases,therefore main-taining mitochondrial functional homeostasis is a potential therapeutic target for OA.Mitophagy is a process of targeted clear-ance and phagocytic dysregulated or damaged mitochondria to maintain mitochondrial homeostasis,which suggests that the reg-ulation of mitophagy may be a potential mechanism of OA treatment.In this paper,through reviewing the recently published lit-erature about mitophagy and OA,the role of mitophagy in the pathogenesis of OA is discussed,providing theoretical research for mitophagy,and emphasizing the potential of targeting autophagy to treat degenerative joint diseases.
