The key role of liquid-liquid phase separation in atherosclerosis
10.20039/j.cnki.1007-3949.2025.03.001
- VernacularTitle:液-液相分离在动脉粥样硬化中的关键作用
- Author:
Fangyao ZHAO
1
;
Junhao LI
;
Ke YANG
;
Hongjun YANG
Author Information
1. 中国中医科学院医学实验中心,北京市 100700;中国计量大学生命科学学院,浙江省 杭州市 310018
- Publication Type:Journal Article
- Keywords:
liquid-liquid phase separation;
atherosclerosis;
research progress;
application prospect
- From:
Chinese Journal of Arteriosclerosis
2025;33(3):185-193,201
- CountryChina
- Language:Chinese
-
Abstract:
Liquid-liquid phase separation is an important process in which intracellular biomolecules condense to form membraneless organelles,playing a significant role in cell signaling and gene expression regulation.Studies have shown that liquid-liquid phase separation may be involved in the occurrence and development of atherosclerosis and has po-tential applications in the diagnosis and treatment of the disease.This article introduces the concept and mechanism of liquid-liquid phase separation,delves into the relationship between liquid-liquid phase separation and atherosclerosis,sum-marizes the progress of liquid-liquid phase separation in atherosclerosis research,and looks forward to its application pros-pects.
