Disrupted aperiodic neural activity and differential cognitive correlates in patients with schizophrenia
10.3969/j.issn.1000-6729.2025.06.01
- VernacularTitle:精神分裂症患者非周期性脑电信号与认知功能的相关性
- Author:
Kexin ZHANG
1
;
Yilin YUAN
;
Tianhang ZHOU
;
Tingfang WU
;
Chunyu DU
;
Chenmei XIE
;
Weiran CHEN
;
Jing WANG
;
Xin YU
Author Information
1. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京 100083
- Publication Type:Journal Article
- Keywords:
schizophrenia;
cognitive performance;
electroencephalography;
power spectral density;
1/f slope
- From:
Chinese Mental Health Journal
2025;39(6):477-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the aperiodic components(1/f slopes)and their associations with cognitive impairment in patients with schizophrenia.Methods:Nineteen patients with schizophrenia according to the Interna-tional Statistical Classification of Diseases and Related Health Problem,Tenth Revision(ICD-10)and 21 normal controls were administrated the total Brief Assessment of Cognition in Schizophrenia(BACS)to measure the cogni-tive performance.The 5-minute eyes-closed and eyes-open resting EEG signals were collected and parameterized in-to aperiodic components(1/f slope).Finally,Pearson correlation was used to examine the relationships between the 1/f slope and cognition assessment scores.Results:The patients with schizophrenia had higher 1/f slope compared to HC on central location of scalp(P＜0.05).The vocal memory scores showed a significantly positive relation with 1/f slopes in patients with schizophrenia(anterior location:r=-0.68,P＜0.05;central location:r=-0.44,P＜0.05),but a significantly negative relation in normal controls(anterior location:r=0.57,P＜0.05;posterior lo-cation:r=0.54,P＜0.05).Conclusion:The 1/f slopes of EEG in schizophrenia were steeper than normal control,suggesting its strong cognitive functional significance and complex mechanisms in schizophrenia.
