Research progress on the mechanisms of cancer-associated fibroblasts in promoting the development of pancreatic cancer
10.3760/cma.j.cn113884-20240802-00235
- VernacularTitle:肿瘤相关成纤维细胞促进胰腺癌发展机制的研究进展
- Author:
Shengfeng ZHANG
1
;
Zhaowei DING
1
;
Ping WANG
1
Author Information
1. 广州医科大学附属第一医院肝胆外科，广州 510120
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Cancer-associated fibroblasts;
Heterogeneity;
Tumour microenvironment
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated fibroblasts (CAFs) play a crucial role in promoting the invasion, metastasis, angiogenesis, immune suppression, and drug resistance of pancreatic cancer. The diverse origins, and phenotypic and functional heterogeneity of CAFs poses a significant challenge for targeted anti-tumor therapies against CAFs. However, investigating the interactions between CAFs and pancreatic cancer cells can provide insights for innovative CAFs-targeted therapies for pancreatic cancer. This article reviews the current domestic and international researchs, focusing on the heterogeneity of CAFs and their mechanisms in the progression of pancreatic cancer, with the aim of providing a theoretical basis and research direction for the clinical diagnosis and treatment of pancreatic cancer.
