Advances in eradicating covalently closed circular DNA of hepatitis B virus by the CRISPR/Cas9 gene editing system
10.3760/cma.j.cn113884-20240730-00231
- VernacularTitle:CRISPR/Cas9基因编辑系统清除乙型肝炎病毒共价闭合环状DNA的研究进展
- Author:
Jiayin YANG
1
;
Yanfeng YIN
Author Information
1. 云南大学生命科学学院，昆明 650000
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Clustered regularly interspaced short palindromic repeats;
CRISPR-associated protein 9
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
After hepatitis B virus (HBV) infection, numerous patients will develop serious sequelae such as liver failure and liver cancer. Finding a way to eradicate HBV has emerged as a top priority for the treatment of HBV infection. Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) gene editing system represents a potent tool for genome manipulation. Many studies have confirmed the capability of the CRISPR/Cas9 gene editing system to remove the covalently closed circular DNA of HBV in cells, which has great potential for application in the treatment of chronic HBV infection. This article summarizes the application status and research progress of CRISPR/Cas9 system in anti-HBV infection, and explores the challenges that may be encountered.
