Research progress on the role of myeloid-derived suppressor cells in tuber-culosis
10.12138/j.issn.1671-9638.20256620
- VernacularTitle:髓源性抑制细胞(MDSCs)在结核病中的作用研究进展
- Author:
Jiaxue ZHANG
1
;
Xiaoping WANG
;
Li LIU
;
Qinmei MA
;
Guangcun DENG
;
Xiaoling WU
Author Information
1. 宁夏大学生命科学学院,宁夏银川 750021;宁夏大学西部特色生物资源保护与利用教育部重点实验室,宁夏银川 750021
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
myeloid-derived suppressor cell;
immunosuppression
- From:
Chinese Journal of Infection Control
2025;24(5):712-720
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis,as a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)infection,presenting a serious threat to human and animal health.When human body is infected by MTB,it quickly initiates an immune response,in which T lymphocyte-mediated cellular immunity plays a key role,as it can effectively recog-nize and eliminate MTB,serving as an important defense line for the body against MTB.However,during MTB in-fection process,myeloid-derived suppressor cells(MDSCs)undergo amplification and activation,which exhibit in-hibitory effect on the immune function of T lymphocytes and interfere the normal immune response of the body,making MTB easier to survive and reproduce in the body.This article discusses the role of MDSCs in the occu-rrence,development and prognosis of tuberculosis from two different perspectives,expects to provide new perspec-tives and ideas for the immunotherapy of tuberculosis as well as the research and development of targeted drugs,so as to open up a new way for the prevention and treatment of tuberculosis.
