Research advance on the role of microglia in retinal inflammation
10.13431/j.cnki.immunol.j.20250017
- VernacularTitle:小胶质细胞作用于视网膜炎症的研究进展
- Author:
Xiangjun CHEN
1
;
Tong ZHOU
1
;
Ling ZHU
1
;
Yuhan LIU
1
;
Jiangning XU
1
Author Information
1. 401331,重庆医药高等专科学校医学技术学院
- Publication Type:Journal Article
- Keywords:
Microglia;
Inflammation;
Retinal disease
- From:
Immunological Journal
2025;41(2):117-122
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of a variety of retinal diseases are related to inflammatory responses,and various inflammatory cells play an important role in retinal damage,which can lead to vision impairment,vision loss,and blindness.Microglia are resident immune cells in the retina,distributed in the inner layer of the retina.They mainly maintain the normal homeostasis of the retina,regulate the apoptosis of neurons,and play an immune surveillance role in the retina.Under inflammatory stimulation,microglia in the retina are activated,secrete a variety of inflammatory factors,engulf neurons and photoreceptors,and destroy the blood-retinal barrier,aggravating retinal damage.This article reviews the physiological function of microglia and the changes in microglia under the inflammatory effects of various retinal diseases.It also discusses how to inhibit microglia from damaging the retina and promote microglia to control retinal inflammation,thereby providing a basis for the clinical treatment of various retinal diseases.
