Research progress on organoid construction and application in pancreatic cancer
10.3760/cma.j.cn113884-20241028-00320
- VernacularTitle:胰腺癌类器官构建与应用的研究进展
- Author:
Jiaxin ZHANG
1
;
Lin XIAO
;
Yueshui ZHANG
;
Kailian ZHENG
;
Gang JIN
Author Information
1. 海军军医大学（第二军医大学）基础医学院，上海 200433
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Organoids;
Drug screening;
Clinical application
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(1):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is an extremely malignant tumor of digestive system, featuring high heterogeneity and poor prognosis. The emergence of pancreatic cancer organoids has provided a new perspectivel for the study of pancreatic cancer. Organoids can accurately simulate the tumor microenvironment and biological characteristics, and reveal the interaction between the tumor and the microenvironment. This article elaborates on the important of organoids in simulating tumor microenvironment, establishing drug screening platform, drug resistance mechanism and promoting personalized therapy. At the same time, the challenges faced by organoids, such as high cost and long modeling time, were analyzed. Pancreatic cancer organoids will play a greater role in personalized treatment and bring new breakthroughs in the research and treatment of pancreatic cancer.
