Research progress on the role of proteasome in the pathogenesis of Alzheimer disease
10.3969/j.issn.1002-0152.2024.11.009
- VernacularTitle:蛋白酶体在阿尔茨海默病发病机制中的作用研究进展
- Author:
Qing WANG
1
;
Lei YE
;
Yun XU
Author Information
1. 南京医科大学鼓楼临床医学院,南京 210008
- Publication Type:Journal Article
- Keywords:
Proteasome;
20S proteasome;
20S proteasome;
Immunoproteasome;
Alzheimer disease;
Ubiquitin proteasomal system;
Proteostasis
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(11):688-693
- CountryChina
- Language:Chinese
-
Abstract:
Due to the insufficient understanding of the pathogenesis of Alzheimer disease(AD),investigating the early pathophysiological mechanisms underlying AD is particularly essential for advancing subsequent drug therapies. Abnormal protein accumulation is a hallmark characteristic of neurodegenerative diseases such as AD and a sign of proteostasis imbalance. The proteasome plays a remarkable role in maintaining proteostasis mainly by degrading abnormal proteins or polypeptides through ubiquitin-proteasome system (UPS). proteasomes interact with amyloid β-protein (Aβ) and Tau protein in β as both cause and effect which in turn affect neuronal function,glial homeostasis and neural circuit regulation. It has been found that proteasome interacts with Aβ and Tau proteins as both cause and effect,which in turn impacts neuronal function,glial homeostasis and neural circuit regulation. A thorough understanding of the relationship between the proteasome and AD not only provides new clues for exploring the pathogenesis of AD but also holds promise as a major therapeutic target in the future.
