Clinical characteristics of co-infection of Talaromyces marneffei and non-tuberculous Mycobacterium in HIV-negative patients
10.12138/j.issn.1671-9638.20256486
- VernacularTitle:HIV阴性患者马尔尼菲篮状菌和非结核分枝杆菌共感染的临床特征
- Author:
Sha LI
1
;
Xiaoyan XIE
1
;
Tingting LIANG
1
;
Jun LIU
1
;
Yaoqin HE
1
;
Fengquan FENG
1
;
Meizhen HUANG
1
;
Qian LI
1
Author Information
1. 南宁市第四人民医院内科,广西南宁 530023
- Publication Type:Journal Article
- Keywords:
Talaromycesmarneffei;
non-tuberculous Mycobacterium;
human immunodeficiency syndrome;
anti-interferon-γ autoantibody;
HIV-negative patient
- From:
Chinese Journal of Infection Control
2025;24(5):591-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of co-infection of Talaromyces marneffei(TM)and non-tuberculous Mycobacterium(NTM)in human immunodeficiency virus(HIV)-negative patients.Methods Clinical data of 8 HIV-negative patients with co-infection of TM and NTM in a hospital from 2019 to 2022 were co-llected.Clinical manifestations,auxiliary examination,treatment and prognosis were retrospectively analyzed.Results Among the 8 patients,5 were females and 3 were males,with an average age of(52.25±12.31)years old.All patients presented TM and NTM disseminated infection.The major involved organs were lung(100％),lymph nodes(87.5％),and skin(75.0％).Clinical symptoms mainly included cough and expectoration(87.5％),fatigue(62.5％),joint and lumbosacral pains(62.5％),fever(50.0％),as well as skin and soft tissue abscess(50.0％),etc.Anti-interferon-γ(INF-γ)autoantibodies were detected in 4 patients and the results were positive.All 8 patients(100％)had pulmonary lesions,with chest CT mainly showing spots,patches,and striped shadows in both lungs.Among them,7 cases(87.5％)had increased and enlarged mediastinal lymph nodes,4 cases(50.0％)had pleural thickening and pleural effusion,2 cases each(25.0％for each)were accompanied by pulmonary mass shadows,bronchial stenosis,as well as increased and enlarged hilar lymph nodes.One case each(12.5％for each)had pulmonary cavity formation,bronchiectasis,and pericardial effusion.Conclusion The co-infection of TM and NTM in non-HIV patients presents disseminated infection,with multiple clinical symptoms.Chest imaging shows a wide variety of pulmonary lesions.It is prone to miss diagnosis in clinic,and the effect is not ideal after treatment for single pathogen infection.
