Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis
10.20039/j.cnki.1007-3949.2025.03.010
- VernacularTitle:脂肪量和肥胖相关蛋白介导的N6-腺苷酸甲基化在动脉粥样硬化中的研究进展
- Author:
Zhuoyi XIE
1
;
Songtao CHEN
;
Xuan SUN
;
Peijuan YANG
;
Yali CHEN
;
Qinjun GUI
;
Jianhong ZUO
Author Information
1. 南华大学衡阳医学院转化医学研究所,湖南省衡阳市 421001
- Publication Type:Journal Article
- Keywords:
fat mass and obesity-related protein;
N6-methyladenosine;
atherosclerosis
- From:
Chinese Journal of Arteriosclerosis
2025;33(3):257-263
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine(m6A)is the most common mRNA modification in eukaryotes,and fat mass and obesity-related protein(FTO),are its demethylases,which efficiently remove the modification of m6A mRNA,and is strongly associated with obesity.Atherosclerosis is a chronic inflammatory lesion of the blood vessel wall driven by lipids.It was found that FTO-mediated m6A may influence the process of atherosclerosis through lipid metabolism,oxidative stress,mitochondrial dysfunction,and macrophage foaminess.
