Effects of hyperbaric oxygen on quality of life and immune function of brain tumor patients undergoing postoperative radiotherapy
10.3760/cma.j.cn311847-20200224-00064
- VernacularTitle:高压氧辅助治疗对脑肿瘤术后放疗患者生命质量及免疫功能指标的影响
- Author:
Gang LIU
1
;
Yuanxin GUO
1
;
Kai HUO
1
Author Information
1. 030002 太原，山西省肿瘤医院神经外科
- Publication Type:Journal Article
- Keywords:
Brain tumor;
Hyperbaric oxygen;
Immune function;
Quality of life
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(3):309-311,315
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of hyperbaric oxygen (HBO) on the quality of life and immune function in patients with brain tumors undergoing postoperative radiotherapy.Methods:A total of 100 patients with brain tumors admitted in Shanxi Provincial Cancer Hospital from December 2015 to December 2017 were selected as the research objects and divided into observation group and control group by the random number table method, with 50 cases in each group. Patients in both groups received conventional radiotherapy 2-4 weeks after operation. Patients in the observation group received HBO 30 minutes before the same treatment of the control group. The incidence of radiation-induced brain injury complications during treatment was recorded. Patients′ peripheral venous blood was collected before and after treatment, and the peripheral blood CD3 + , CD4 + , and CD8 + levels were measured. Both groups were followed up for one year after treatment, and the one-year survival rate was recorded. The 36-Item Short Form Health Survey (SF-36) was used to evaluate the patients′ quality of life one year after treatment. Results:After treatment, the incidence of radiation-induced brain injury complications in the observation group (14%) was significantly lower than that in the control group (50%), with statistical difference ( P<0.01). After treatment, the percentage of peripheral blood CD4 + cells and the ratio of CD4 + / CD8 + in the observation group were significantly increased ( P<0.01), and were significantly higher than those in the control group after treatment ( P<0.01). The one-year survival rate in the observation group after treatment (84.0%, 42/50) was significantly higher than that in the control group (66.0%, 33/50) ( P<0.05). Compared with the control group, the patients in the observation group had significantly higher scores in physical functioning, physical role functioning, general health perceptions, social role functioning, and mental health one year after treatment ( P<0.05). Conclusion:HBO therapy can improve the immune function and quality of life of brain tumor patients undergoing postoperative radiotherapy.
