Clinical efficacy of hyperbaric oxygen combined with atorvastatin on patients with coronary heart disease and its effects on hemorheological indexes
10.3760/cma.j.cn311847-20191217-00398
- VernacularTitle:高压氧联合阿托伐他汀治疗冠心病患者的临床疗效及对血液流变学指标的影响
- Author:
Hailiang YU
1
;
Shichao ZHAO
1
;
Chenghua LIU
1
;
Yang ZHANG
1
Author Information
1. 276400 山东省临沂，临沂市中心医院心内科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Atorvastatin;
Coronary heart disease;
Clinical efficacy;
Hemorheology
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(3):279-282
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical efficacy of hyperbaric oxygen (HBO) combined with atorvastatin on patients with coronary heart disease and its effects on the changes of hemorheological indexes.Methods:A total of 150 patients with coronary heart disease admitted to the Department of Cardiology of Linyi Central Hospital from December 2016 to December 2018 were included into a retrospective analysis, who were randomly divided into the combination group and the control group, with 75 cases each. The control group was treated with atorvastatin on the basis of routine treatment, and the combination group was treated with HBO on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared after the treatment, and the changes of vascular inflammatory factors, D-dimer, and hemorheological indexes were compared before and after treatment.Results:After HBO combined with atorvastatin treatment, the total clinical effective rate of the combination group was 93.33%, which was significantly higher than that of the control group (82.67%) ( χ2=4.040, P<0.05); after 4 courses of treatment, the levels of hs-CRP, Lp-PLA2, LDL-C, and D-dimer in the two groups were significantly lower than those before treatment ( P<0.05), and those in the combination group were significantly lower than those in the control group ( P<0.05); after the treatment, the hemorheological indexes, i. e. whole blood high shear viscosity, whole blood middle shear viscosity, whole blood low shear viscosity, plasma viscosity, and fibrinogen, in the two groups were statistically significant lower than those before treatment ( P<0.05), and those in the combination group were significantly lower than those in the control group ( P<0.05). Conclusion:HBO combined with atorvastatin has a significant clinical effect in the treatment of coronary heart disease, which can significantly reduce the inflammatory reaction of blood vessels, and improve the hemorheological indexes.
