Research Progress of Role and Mechanism of TIM-3 in Colorectal Cancer
10.3969/j.issn.1008-7125.2024.05.009
- VernacularTitle:TIM-3在结直肠癌中作用和机制的研究进展
- Author:
Mengnan DAI
1
;
Yingwei ZHU
;
Jian LU
;
Lili ZHANG
;
Hong TANG
Author Information
1. 南京医科大学(211166)
- Publication Type:Journal Article
- Keywords:
T Cell Immunoglobulin and Mucin Domain-Containing Protein 3;
Colorectal Neoplasms;
Ligands;
T-Lymphocytes;
Macrophages;
Dendritic Cells;
Immunotherapy
- From:
Chinese Journal of Gastroenterology
2024;29(5):308-314
- CountryChina
- Language:Chinese
-
Abstract:
T cell immunoglobulin and mucin domain-containing protein 3(TIM-3)is a newly discovered inhibitory immune checkpoint receptor molecule that is widely expressed on the surface of immune cells and plays a vital inhibitory role in both innate and adaptive anti-tumor immunity.TIM-3 can be expressed on the surface of tumor cells,directly facilitating the occurrence and progression of tumor.TIM-3 is closely related to the occurrence,metastasis,prognosis and treatment of colorectal cancer by acting on various cells in the tumor microenvironment and promoting the formation of tumor-suppressive microenvironment.TIM-3 can serve as a molecular target for prognosis and immunotherapy of colorectal cancer,enhancing the application value of immunotherapy in colorectal cancer.This article reviewed the expression and potential mechanism of TIM-3 in the tumor microenvironment of colorectal cancer and its correlation with the prognosis and treatment of colorectal cancer.
