Drug-induced Constipation:Summarization of Common Drugs Causing Constipation and Strategies for Prevention and Treatment

VernacularTitle:药物性便秘:常见致便秘药物总结和防治策略
Author: Ying KANG ¹ ; Meifeng WANG ; Yurong TANG ; Fangyu WANG ; Lin LIN
Author Information

1. 东部战区总医院消化内科(210002);南京医科大学第一附属医院消化内科
Publication Type:Journal Article
Keywords: Constipation; Drugs; Prevention; Therapy
From: Chinese Journal of Gastroenterology 2024;29(5):297-302
CountryChina
Language:Chinese
Abstract: Constipation is a common clinical symptom,often secondary to drugs or other disorders.Various common drugs such as analgesics,anticholinergic drugs,5-hydroxytryptamine receptor antagonists,etc.,can induce constipation,namely drug-induced constipation.This article categorized the common drugs that trigger constipation,analyzed and summarized the pharmacological mechanisms,classification,relevant clinical trials and animal experiment data,in order to guide clinicians in the prevention and treatment of drug-induced constipation through adjusting drugs or administration routes,modifying lifestyles,and using laxatives or peripherally acting μ-opioid receptor antagonists rationally.