Application of Mendelian randomization analysis in age-related macular de-generation
10.13389/j.cnki.rao.2025.0014
- VernacularTitle:孟德尔随机化分析在年龄相关性黄斑变性研究中的应用
- Author:
Wenfeng ZHANG
1
;
Qiongtao SONG
;
Chunmeng LIU
;
Lu CHANG
;
Fuwen ZHANG
Author Information
1. 610075 四川省成都市,成都中医药大学;610075 四川省成都市,中医药眼病防治与视功能保护四川省重点实验室
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
Mendelian randomization;
causal inference
- From:
Recent Advances in Ophthalmology
2025;45(1):71-76
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(AMD)is a degenerative disease caused by multiple factors,and it is one of the leading causes of severe vision loss.Mendelian randomization(MR)uses genetic variation as an instrumental varia-ble to detect and quantify the causal relationship between exposure and outcomes,overcoming the limitations of observa-tional studies and randomized controlled trials.In recent years,MR has been widely used in the etiological inference of AMD.In this paper,MR studies related to AMD are summarized,focusing on the causal relationship between different risk factors and the onset of AMD,so as to provide a basis for the etiological research and prevention strategy development of AMD.
