Causal Relationship Between Gut Microbiota and Duodenal Ulcer:A Two-sample Mendelian Randomization Study
10.3969/j.issn.1008-7125.2024.05.004
- VernacularTitle:肠道菌群与十二指肠溃疡的因果关系:双样本孟德尔随机化研究
- Author:
Yaqi HOU
1
;
Yuan LI
;
Lixuan YAN
;
Wanli GONG
;
Yang WANG
;
Xuechun LU
;
Peifeng HE
;
Qi YU
Author Information
1. 山西医科大学管理学院(030600);临床决策研究大数据山西省重点实验室
- Publication Type:Journal Article
- Keywords:
Gut Microbiota;
Duodenal Ulcer;
Causal Relationship;
Mendelian Randomization Analysis
- From:
Chinese Journal of Gastroenterology
2024;29(5):276-282
- CountryChina
- Language:Chinese
-
Abstract:
Background:The diversity and function of gut microbiota have been regarded as crucial factors affecting human health.With the advances in genetics and epidemiology,especially the application of Mendelian randomization analysis,a novel perspective has been provided for profoundly uncovering the causal relationship between gut microbiota and duodenal ulcer.Aims:To investigate the causal relationship between gut microbiota and duodenal ulcer through two-sample Mendelian randomization analysis.Methods:Genetic variation samples of the gut microbiota were screened from the MiBioGen database.Genetic loci related to duodenal ulcer were selected as instrumental variables from genome-wide association study.The inverse-variance weighted method,weighted median method,and MR-Egger regression analysis were used to assess the causal relationship between gut microbiota and duodenal ulcer.Tests for heterogeneity and horizontal pleiotropy were conducted to ensure the stability of the results.Results:Bacteroides(OR=0.998,95%CI:0.996-1.000,P=0.014),Prevotella_7(OR=0.999,95%CI:0.998-1.000,P=0.043)and Terrisporobacter(OR=0.998,95%CI:0.997-1.000,P=0.029)exhibited negative causal relationship with duodenal ulcer,while Bifidobacterium(OR=1.001,95%CI:1.000-1.003,P=0.046),Lachnoclostridium(OR=1.002,95%CI:1.001-1.004,P=0.007)and Olsenella(OR=1.001,95%CI:1.000-1.002,P=0.018)presented positive causal relationship with duodenal ulcer.The sensitivity analysis indicated that the influences of heterogeneity and horizontal pleiotropy on the causal relationship could be excluded.Conclusions:The two-sample Mendelian randomization analysis revealed that Bacteroides,Prevotella_7 and Terrisporobacter were protective factors for duodenal ulcer,while Bifidobacterium,Lachnoclostridium and Olsenella were risk factors.
