Molecular Mechanism of Gentiopicroside on Diseases
- VernacularTitle:龙胆苦苷作用于疾病的分子机制
- Author:
Mingxiu LI
1
;
Qingsong LI
;
Xiaotong YANG
;
Ruifeng YANG
;
Lili WU
;
Tonghua LIU
;
Lingling QIN
Author Information
- Publication Type:Journal Article
- Keywords: Gentiopicroside; Mechanism research; Pharmacokinetics; Diabetes mellitus; Liver disease; Bone and joint diseases
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(4):950-961
- CountryChina
- Language:Chinese
- Abstract: Gentiopicroside(GPS)is the main active ingredient extracted from Gentiaceae.It has anti-inflammatory,antioxidant,analgesic,anti-fibrosis,inhibition of tumor cell proliferation and improvement of glucose and lipid metabolism.Gentiaceae shows a wide range of application prospects in the treatment of diabetes,liver diseases,bone and joint diseases and other diseases.This paper reviewed the pharmacokinetics of gentiopicrin,including its pharmacokinetic properties in different animal models,and its mechanism and targets in the treatment of diabetes mellitus and its complications,liver injury,bone and joint diseases.Studies have shown that gentiopictin exerts its therapeutic effects by regulating various signaling pathways,such as PI3K/AKT,FOXO1,PPAR-γ,NF-κB,etc.Although the current research has made some progress,there are still limitations,such as most studies focused on animal models and in vitro experiments,lack of high-quality clinical evidence-based trials support.Future studies should further explore the new targets and signal transduction pathways of gentiopicroside,improve its bioavailability,and strengthen the research of traditional Chinese medicine compounds,so as to give full play to the advantages of holistic treatment of traditional Chinese medicine.
