Observation on the curative effect of hyperbaric oxygen assisted treatment on 55 cases of fetal growth restriction
10.3760/cma.j.cn311847-20200227-00068
- VernacularTitle:高压氧辅助治疗胎儿生长受限55例疗效观察
- Author:
Yan LU
1
;
Rong MA
;
Yixuan WANG
;
Yaoyue ZHANG
;
Qiong LAN
;
Junning JING
Author Information
1. 730050 兰州，甘肃省妇幼保健院功能科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Color Doppler ultrasound;
Fetal growth restriction;
Blood flow parameters;
Maternal and infant outcomes;
Coagulation
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(3):327-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of hyperbaric oxygen (HBO) assisted treatment on fetal growth restriction (FGR).Methods:A total of 110 pregnant women with FGR admitted in Gansu Provincial Maternity and Child-care Hospital from June 2018 to June 2019 were selected as research objects. They were randomly divided into observation group and control group in a ratio of 1∶1, with 55 cases in each group. The control group was treated with low molecular heparin combined with aspirin, and the observation group was treated with HBO on the basis of the treatment of the control group for 6 weeks. The fetal growth was examined by color Doppler ultrasound. The clinical effect and fetal hemodynamic parameters before and after treatment were compared. The maternal and infant outcomes such as complications of pregnancy and neonatal conditions were statistically analyzed. The coagulation functions of pregnant women before and after treatment were also analyzed.Results:The effective rate of the observation group (83.64%) was significantly higher than that of the control group (63.64%) with statistical difference ( χ2=5.666, P=0.017). After treatment, the high systolic blood flow/late diastolic blood flow (S/D), resistance index (RI), and pulse index (PI) of the two groups were all remarkably decreased ( P<0.01), and those of the observation group were lower than those of the control group ( P<0.05) before and after treatment. There was no statistical difference in the comparisons of neonatal complications and pregnancy complications after treatment between the two groups ( P>0.05). The coagulation function index of both two groups after treatment were all improved than those before treatment with statistically significant difference ( P<0.05), but there was no statistically significant difference between the coagulation function index of the observation group and that of the control group after treatment( P>0.05). Conclusion:HBO combined with aspirin and low molecular heparin in the treatment of FGR can significantly improve the fetal hemodynamic parameters, and therefore improve the clinical efficacy.
