Research Advances in Molecular Mechanism of Cardiac Fibrosis Related to Atrial Fibrillation
10.3969/j.issn.1000-3614.2024.12.012
- VernacularTitle:心房颤动心肌纤维化的分子机制研究进展
- Author:
Yuzhu CHEN
1
;
Yu QIAO
;
Yahong LIU
;
Guodong NIU
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心律失常中心,北京 100037
- Publication Type:Journal Article
- Keywords:
atrial fibrillation;
cardiac fibrosis;
molecular mechanism;
signal pathway
- From:
Chinese Circulation Journal
2024;39(12):1229-1233
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of atrial fibrillation is complex and individualized.Cardiac fibrosis plays an important role in the occurrence,recurrence,complications,and treatment of atrial fibrillation by participating in cardiac structural and electrical remodeling.Studies have shown that cardiac fibrosis is associated with extensive neurohumoral regulation and complicated molecular interactions and is regulated by multiple signal pathways.Therefore,cardiac fibrosis is expected to be an effective and promising intervention target for atrial fibrillation.This review article summarizes the current intracellular and extracellular molecular mechanisms of cardiac fibrosis in atrial fibrillation aiming to provide new ideas for the prevention and treatment of atrial fibrillation.
