Research progress on the mechanism of melanoma brain metastasis
10.3760/cma.j.cn114453-20230921-00060
- VernacularTitle:黑色素瘤脑转移机制研究进展
- Author:
Ayoujiang AYIDANA
1
;
Tianyi LIU
Author Information
1. 复旦大学附属华东医院整形外科，上海 200040
- Publication Type:Journal Article
- Keywords:
Melanoma;
Brain neoplasms;
Neoplasm metastasis;
Tumor microenvironment;
Signal transduction
- From:
Chinese Journal of Plastic Surgery
2025;41(2):217-222
- CountryChina
- Language:Chinese
-
Abstract:
Melanoma is a highly malignant tumor characterized by a high incidence of brain metastases and poor prognosis. This review summarizes recent advances in understanding the mechanisms underlying melanoma brain metastases. The metastatic process involves genetic mutations, such as BRAF mutations, and dysregulated signaling pathways, including the overactivation of the PI3K/AKT pathway, as well as a variety of complex molecular mechanisms. Moreover, melanoma cells interact intricately with the brain microenvironment, including astrocytes and microglia, during the progression of brain metastases. Elucidating these mechanisms provide valuable insights for developing more effective diagnostic and therapeutic strategies, offering novel perspectives for clinical management.
