Application and prospects of Mendelian randomization in diabetic retinopa-thy
10.13389/j.cnki.rao.2025.0001
- VernacularTitle:孟德尔随机化在糖尿病视网膜病变研究中的应用与展望
- Author:
Xiaorong LI
1
;
Shaojie REN
1
Author Information
1. 300384 天津市,天津医科大学眼科医院、眼视光学院、眼科研究所国家眼耳鼻喉疾病临床医学研究中心天津市分中心天津市视网膜功能与疾病重点实验室
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
Mendelian randomization;
single nucleotide polymorphism;
causal inference
- From:
Recent Advances in Ophthalmology
2025;45(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is a common ocular complication in patients with diabetes and one of the leading causes of blindness in adults.Due to the complex pathological mechanism of DR and its close relationship with other meta-bolic disorders,it has become an urgent need in the field of public health to explore its etiology and develop effective pre-vention and treatment methods.As a new causal inference method,Mendelian randomization(MR)can effectively control the influence of confounding factors and inverse causality by using genetic variations to infer the causal relationship between exposure and diseases.The purpose of this paper is to introduce the application and research progress of MR in the investi-gation of the etiology of DR and analyze the limitations of current research and the future development direction.
