Efficacy of a cetyl alcohol-containing moisturizing cream in improving symptoms and preventing relapse during the remission phase of mild to moderate infantile atopic dermatitis
10.3760/cma.j.cn114798-20250509-00397
- VernacularTitle:某种含鲸蜡醇保湿霜对婴儿期轻中度特应性皮炎缓解期症状改善及复发预防的效果
- Author:
Shan WANG
1
;
Mutong ZHAO
1
;
Chunping SHEN
1
;
Ying LIU
1
;
Ying GU
1
;
Lei JIAO
1
;
Jing TIAN
1
;
Jing SUN
1
;
Yang WANG
1
;
Qiong WU
1
;
Yuan LIANG
1
;
Lin MA
1
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院皮肤科，北京 100045
- Publication Type:Journal Article
- Keywords:
Atopic dermatitis;
Children;
Relapse;
Emollient;
Remission phase
- From:
Chinese Journal of General Practitioners
2025;24(7):834-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of a cetyl alcohol-containing moisturizing cream (referred to as the emollient) in improving clinical symptoms and preventing disease relapse during the remission phase of mild to moderate infantile atopic dermatitis (AD).Methods:A single-center, investigator-blinded, randomized controlled clinical trial was conducted from February 2022 to October 2023. Sixty participants aged >28 days to ≤2 years with mild to moderate AD (Investigator′s Global Assessment (IGA) score 2 or 3) and controlled disease (IGA 0 or 1) were enrolled. Participants were randomized 1∶1 to either the experimental group (topical emollient applied twice daily combined with a moisturizing cleanser for daily bathing) or the control group (moisturizing cleanser alone). Assessments at weeks 2, 4, 8, and 12 included AD relapse rates, clinical severity scores (IGA and Eczema Area and Severity Index (EASI)), and adverse events.Results:Fifty-six participants were included in the full analysis set. The median time to relapse was 12.0 (6.0-72.0) days in the experimental group versus 8.5 (3.0-19.0) days in the control group (log-rank test: χ2=3.079, P=0.213). Relapse rates were 80.77% (21/26) in the experimental group and 95.83% (23/24) in the control group ( χ2=2.682, P=0.101). The experimental group showed significantly lower IGA scores at weeks 2 and 12 ( P<0.05) and lower EASI scores at weeks 4 and 12 ( P<0.05). Adverse event rates were 8.0% (2/25) and 7.7% (2/26) in the experimental and control groups, respectively ( χ2=0.002, P>0.05) Conclusion:The combination of the cetyl alcohol- containing moisturizing cream and moisturizing cleanser during AD remission may improve clinical symptoms and modestly delay relapse, with a low incidence of adverse events.
