Cross-kingdom Regulation by Plant miRNAs and Its Implications for the Study of Medicinal Substances of Traditional Chinese Medicine
- VernacularTitle:植物miRNA跨界调控及对中药药效物质研究的启示
- Author:
Miao ZHANG
1
;
Xiaohui TAN
;
Yingcai WU
;
Yanling ZHENG
;
Lijuan WU
;
Zhenfei WANG
Author Information
- Publication Type:Journal Article
- Keywords: Plant miRNAs; Cross-kingdom regulation; Human diseases; Chinese medicine; Pharmacology
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(4):924-930
- CountryChina
- Language:Chinese
- Abstract: MicroRNA(miRNA),an important type of non-coding RNAs existing widely in viruses and eukaryotes,regulate gene expression at transcriptional and post-transcriptional levels.Recent studies have demonstrated that plant miRNAs could enter microorganisms,animals and human bodies to affect their physiological and pathological processes by cross-kingdom regulation of gene expression.This review summarized the current knowledge of cross-kingdom regulation of gene expression by plant miRNAs,introduced the research progress in intervention of human diseases with plant miRNAs,including anti-virus,anti-tumor,anti-inflammation,immune regulation,anti-fatigue,anti-fibrosis,vascular protection,nerve protection,etc.,and analyzed the reasons why plant miRNAs remain stable in vivo and in vitro and the underlying mechanisms how they regulate human gene expression.Furthermore,the impact of cross-kingdom regulation by plant miRNAs on exploring new active ingredients of traditional Chinese herbs and elucidating their pharmacology were evaluated.Finally,"constructing the complex regulatory network of traditional Chinese medicine miRNAs in human body"and"exploring new mechanisms of gene expression regulation by traditional Chinese medicine miRNAs"were pointed out,which were two scientific problems worthy of further investigation.
