Causality between immune cells and hepatocellular carcinoma:a Mendelian randomization study
10.13602/j.cnki.jcls.2025.05.09
- VernacularTitle:免疫细胞与肝细胞性肝癌的因果关系:孟德尔随机化研究
- Author:
Yao WANG
1
;
Pu XU
1
;
Yunjie WANG
1
;
Ying DING
1
;
Xiaohua XU
1
;
Zhuo LI
1
Author Information
1. 西安医学院第一附属医院检验科,西安 710077
- Publication Type:Journal Article
- Keywords:
immune cell;
hepatocellular carcinoma;
Mendelian randomization;
tumor microenvironment;
tumor-infiltrating lymphocyte
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(5):362-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective The causal relationship between immune cells and hepatocellular carcinoma(HCC)risk was investigated using a two-sample Mendelian randomization method.Methods The datasets including 731 immune cells and HCC were obtained from the GWAS database and Finngen database,respectively.The stability and reliability of Mendelian randomization studies were evaluated by the MR-Egger regression,MR PRESSO,Cochran's Q test,and leave one out test.The inverse variance weighting,MR-Egger,weigh-ted median,simple mode and weighted mode were used to investigate the causal relationship between immune cells and HCC.Results A total of 4 immune cells were found to have a potential causal relationship with HCC,and the results were stable.The CD3+CD39+Treg,CD80+granulocyte and CD4+Treg were protective factors for HCC(OR=0.910,95%CI:0.852-0.972;OR=0.919,95%CI:0.865-0.975;OR=0.924,95%CI:0.873-0.978),while CD45+CD33+HLA-DR+CD14+marrow cells were a risk factor for HCC(OR=1.116,95%CI:1.033-1.204).Conclusion The CD3+CD39+Treg,CD80+granulocytes,and CD4+Treg are negatively associated with the risk of HCC,while CD45+CD33+HLA-DR+CD14+marrow cells are positively associated with the risk of HCC.
