Research progress on key signaling pathways of alveolar epithelial cell transdifferentiation in the pathogenesis of bronchopulmonary dysplasia
10.3969/j.issn.1672-8467.2025.01.018
- VernacularTitle:支气管肺发育不良发生机制中肺泡上皮细胞转分化关键信号通路的研究进展
- Author:
Meng-yue ZHANG
1
;
Jian-guo ZHOU
Author Information
1. 国家儿童医学中心/复旦大学附属儿科医院新生儿科 上海 201102
- Publication Type:Journal Article
- Keywords:
alveolar epithelial cells;
transdifferentiation;
signaling pathway;
bronchopulmonary dysplasia(BPD)
- From:
Fudan University Journal of Medical Sciences
2025;52(1):133-138
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia(BPD)is a detrimental respiratory complication associated with prematurity that still lacks effective treatment.BPD is a multifactorial disease with a pathogenesis involving alveolar simplification and impaired vascularization.Alveolar epithelial cells are the main components of alveoli including alveolar type Ⅰ(AT1)and alveolar type Ⅱ(AT2)epithelial cells.AT1 cells are involved in constructing the air-blood barrier and facilitating gas exchange,while AT2 cells,characterized by proliferative and differentiated stem cell properties,maintain lung homeostasis and contribute to lung injury.The transdifferentiation of AT2 cells into AT1 cells is a core mechanism in the repair of lung injuries,although the key signaling pathway activating transdifferentiation remains unclear.This article introduces the key signaling pathways and research progress in alveolar epithelial cell transdifferentiation through literature retrieval and classification summary,providing a foundation for elucidating the pathogenesis of BPD and exploring new therapeutic regimens for BPD.
