Harnessing Artificial Intelligence for Advances in Gene Editing
10.13865/j.cnki.cjbmb.2025.02.1321
- VernacularTitle:人工智能驱动的基因编辑技术及其应用
- Author:
Zi-Yue ZHANG
1
;
Xin-Zhi ZHOU
;
Bin LU
Author Information
1. 南华大学,衡阳医学院,基础医学院,细胞与遗传研究所,湖南,衡阳 421001
- Publication Type:Journal Article
- Keywords:
gene editing;
CRISPR/Cas;
artificial intelligence(AI);
data driven
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(4):522-532
- CountryChina
- Language:Chinese
-
Abstract:
Gene editing technology has become an important tool for biomedical research because of its high efficiency and precision in target gene localization and cleavage.The technology not only facilitates basic research on gene function,but also provides new strategies for gene therapy of hereditary diseases and genetic improvement of crops.With the integration of artificial intelligence(AI)technology,espe-cially the application of machine learning algorithms,the design and execution of gene editing have be-come more intelligent.AI technology optimizes the design of sgRNAs through predictive analysis and pat-tern recognition,improving the specificity and efficiency of editing while reducing the risk of off-target effects.In addition,AI plays a key role in the parsing of large-scale genomic data,providing new per-spectives for understanding complex biological processes and disease mechanisms.This paper reviews the research progress of data-driven gene editing technology in target precision,safety enhancement and per-sonalized therapy,aiming to provide reference and inspiration for researchers in the field of gene editing technology and to promote the application and development of AI in gene editing technology.
